朱伟 简历

1.基本情况：

医学博士，教授，博士生导师。bwin必赢病理学技术教研室主任。肿瘤分子病理学研究方向，主要从事结直肠癌等恶性肿瘤侵袭转移分子机制及相关肿瘤标志物研究。主持国家自然科学基金面上项目1项、广东省自然科学基金3项、广东省普通高校特色创新项目1项、广东医科大学博士启动基金1项及广东医科大学科研基金自然科学类重点培育项目1项。第一/通讯（含共同）作者发表SCI收录论文22篇。广东省科学学与科技管理研究会医学研究专业委员会常务委员，湛江市医学会消化道肿瘤学分会第一届专业委员会常务委员，中华结直肠癌MDT联盟湛江地区分会常任委员；广东省自然科学基金评审专家；《Theranostics》等杂志审稿专家。近三年指导的研究生获广东省优秀研究生2人次，国家奖学金3人次，骏腾病理研究生奖学金3人次。获广东医科大学2021年度研究生教育“优秀导师”称号。

2.近5年发表第一/通讯（含共同）作者SCI收录论文

[1] Zhu W^*, Li GX^*, Chen HL, Liu XY^#. The role of eukaryotic translation initiation factor 6 in tumors. Oncol Lett. 2017; 14(1):3-9. (IF:1.39)

[2] Tang J, Yang Z, Wang Z, Li Z, Li H, Yin J, Deng M^#, Zhu W^#, Zeng C^#. Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer. World J Surg Oncol. 2017; 15(1):173-177. (IF:1.6)

[3] Sun Y, Zeng C, Gan S, Li H, Cheng Y, Chen D, Li R, Zhu W^#. LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer. Int J Mol Sci. 2018; 19(2):1-12. (IF: 4.183)

[4] Sun Y^*, Long J^*, Yin Y, Li H, Jiang E, Zeng C^#, Zhu W^#. Characterization of CSF2A fusion gene and its effect on EBV+ tumor cells. J Med Virol. 2018; 90(2):1750-1756. (IF: 2.049)

[5] Yin Y^*, Long J^*, Sun Y, Li H, Jiang E, Zeng C^#, Zhu W^#. The function and clinical significance of eIF3 in cancer. Gene. 2018; 673:130-133. (IF: 2.638)

[6] Long J^*, Yin Y^*, Guo H, Li S, Sun Y, Zeng C^#, Zhu W^#. The mechanisms and clinical significance of PDCD4 in colorectal cancer. Gene. 2019; 680:59-64. (IF: 2. 984)

[7] Tian F^*, Zhan Y^*, Zhu W^*, Li J, Tang M, Chen X, Jiang J. MicroRNA-497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl-2. Int J Mol Med. 2019;43(2):1058-1066. (IF: 3.098)

[8] WEI ZHU^*, JIA-LI LONG^*, YU-TING YIN, HAI-NA GUO, EN-PING JIANG, YU-LING LI, QING-LIAN HE, CHAO ZENG^#, YAN-QIN SUN^#. MicroRNA-34a suppresses the invasion and migration of colorectalcancercells by enhancing EGR1 and inhibiting vimentin. Experimental and Therapeutic Medicine. 2019; 18:2459-2466. (IF:1.785)

[9] Yuting Yin^*, Jiali Long^*, Qinglian He, Yuling Li, Yanqiu Liao, Peishan He, Wei Zhu^#. Emerging roles of circRNA in formation and progression of cancer. Journal of Cancer. 2019; 10(21): 5015-5021. (IF: 3.565)

[10] Qinglian He*, Jiali Long*, Yuting Yin*, Yuling Li, Xue Lei, Ziqi Li, Wei Zhu^#. Emerging Roles of lncRNAs in the Formation and Progression of Colorectal Cancer. Front. Oncol. 2020; 9(1542): 1-11. (IF: 4.848)

[11] Yuting Yin*, Qinglian He*, Yuling Li, Jiali Long, Xue Lei, Ziqi Li, Wei Zhu^#. Emerging functions of PRKDC in the initiation and progression of cancer. Tumori J. 2020; 300891620950472.  (IF: 1.707)

[12] Jiali Long*, Qinglian He*, Yuting Yin, Xue Lei, Ziqi Li, Wei Zhu^#. The effect of miRNA and autophagy on colorectal cancer. Cell proliferation. 2020; 53(10): e12900. (IF: 5.753)

[13] Tian FQ*, Chen ZR*, Zhu W*, Tang MQ, Li JH, Zhang XC, Jiang J, Cheng XH. Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to Bortezomib via miR-874-3p/HDAC1 axis. J Gene Med. 2021 Feb 24:e3329. doi: 10.1002/jgm.3329. Online ahead of print. PMID: 33625798. (IF: 3.258)

[14] Xue Lei^*, Qinglian He^*, Ziqi Li, Qian Zou, Pingrong Xu, Haibing Yu, Yuanlin Ding, Wei Zhu^#. Cancer stem cells in colorectal cancer and the association with chemotherapy resistance. Medical Oncology. 2021;38:43. (IF: 2.834)

[15] Qinglian He, Ziqi Li, Jinbao Yin, Yuling Li, Yuting Yin, Xue Lei and Wei Zhu^#. Prognostic significance of autophagy relevant gene markers in colorectal cancer. Front. Oncol. 2021; 11(1542): 1-11. (IF: 4.848)

[16] Qinglian He, Aihua Ye, Weibiao Ye, Xiaomin Liao, Guoqiang Qin, Yongqiang Xu, Yuting Yin, Huanqian Luo, Muhua Yi, Liying Xian, Shihao Zhang, Xiyuan Qin, Wei Zhu^# and Yuling Li^#. Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1. Cell Death & Disease. 2021;12:576. (IF: 6.304)

[17] Qinglian He^*, Ziqi Li, Xue Lei, Qian Zou, Haibing Yu, Yuanlin Ding, Guangxian Xu, and Wei Zhu^#. The underlying molecular mechanisms and prognostic factors of RNA binding protein in colorectal cancer: A study based on multiple online databases. Cancer Cell International. 2021. (IF: 4.1, pre-accepting)

3.主持课题：

1. 2020年度广东医科大学科研基金自然科学类重点培育项目，GDMUZ2020001，Hsa_circ_013666靶向miR-1301-3p调控PRKDC在结直肠癌浸润转移中的作用及其机制研究，2020.07-2022.06，2.5万，在研，主持。

2. 广东省普通高校特色创新项目，2020KTSCX045，结直肠癌中lncRNA MALAT1胞浆/胞核异位表达受m6A修饰调控临床意义及其出核后调控分子机制研究，2020.09-2022.08，10万，在研，主持。

3. 广东省自然科学基金-自由申请项目，2020A151501303，miR-661靶向MTA1/STAT3通路调控PDCD4/ATG5影响自噬抑制CRC浸润转移及其分子机制研究，2019/09-2022/09，10万+3万，在研，主持。

4. 国家自然科学基金面上项目，81472275，eIF6调控miR-21/PDCD4/MTA1通路促进结直肠癌侵袭转移及机制研究，2015/01-2018/12，72万（配套72万），结题，主持。

5. 广东省自然科学基金-自由申请项目，2014A030313542，真核翻译起始因子eIF6靶向调控结直肠癌侵袭转移的分子机制研究，2014/10-2017/10，10万（配套8万），结题，主持。

6. 广东省自然科学基金-博士启动项目，S2012040006311，结直肠癌中MTA1通过表观遗传修饰调控Maspin促进EMT和血管生成及分子机制，2012/10-2014/10，1+2万，结题，主持。

7. 广东医科大学博士启动基金项目，B2011004，LMP2A和GM-CSF融合基因在EBV相关肿瘤中的作用和分子机制，2012/01-2013/12，20万，结题，主持。